In Parallel to characterising the interaction amongst conolidine and ACKR3, the two groups went a step even more. The researchers developed a modified variant of conolidine — which they referred to as “RTI-5152-twelve” — which completely binds to ACKR3 with a fair increased affinity. Like LIH383, a patented compound previously https://www.proleviate.com/post/conolidine-alkaloid-for-chronic-pain
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