Chimeric antigen receptor (CAR)-T cell therapy shows excellent potency against hematological malignancies. but it remains challenging to treat solid tumors. mainly because of a lack of appropriate antigenic targets and an immunosuppressive tumor microenvironment (TME). The checkpoint molecule programmed death-ligand 1 (PD-L1) is widely overexpressed in multiple tumor types. https://www.isyeriacilisi.com/product-category/pulses-lentils-5/
A novel PD-L1-targeted shark VNAR single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer
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